Dr. Jinhee Choi
PROFESSOR
Schoolof Environmental Engineering, Universityof Seoul
163 Seoulsiripdaero, Dongdaemun-gu, Seoul, 02504,
Republic of Korea
Biography
Jinhee Choi is interested in understanding the molecular mechanism of environmental chemicals-induced toxicity for protection of human and ecosystem health. She did her PhD in Eco-toxicology Lab of University of Paris-Sud (XI), Orsay, France.During her PhD, she conducted multi-bio-marker research in various lab and field scale eco-toxicology projects and identified oxidative stress bio-markers due to chemical exposure in freshwater invertebrates. After her PhD, she did postdoctoral fellowship in Seoul National University, Medical school. While then she investigated DNA repair mechanism due to oxidative DNA damage in various in-vitro and in-vivo and human biopsy samples. Her PhD and postdoctoral experiences were quite different yet both productive and interlinked and were served as a background for her interdisciplinary research in environmental toxicology.When she established her own lab in University of Seoul, School of Environmental Engineering in 2002, she tried to incorporate her multidisciplinary experiences using different model systems. Her interest lies in systemic understanding of molecular mechanism of toxicity due to environmental chemicals exposure. For this, she applies multi-OMICS and systems toxicology technologies,which provide unbiased novel information on chemical toxicity and help to develop mechanistic model for toxicity prediction. The ultimate goal of her research is to bridge the gap between mechanistic toxicological research and the development of useful tools for risk assessment. To this end, she leads a research project on development of adverse outcome pathway (AOP) of inhalation toxicity under OECD program. On the other hand, she is also interested in epigenetic mechanism in environmental chemicals -induced toxicity and human disease development. She conducts environmental epigenetics project also in eco-toxicological contexts, by investigating multi- and trans-generational effect of chronic exposure of chemicals in invertebrates. She has been used various model organisms in human toxicology as well as eco-toxicology contexts and thus her interest naturally lies in cross-species extrapolation of the conserved toxic mechanism. She has been investigated toxicity from various environmental chemicals, with special attention on nano-material’s toxicity. However, as her stressors of interests go beyond chemicals, she recently investigates combined effect of chemicals exposure with physical or biological agents, such as, temperature or microbiome. She is a full professor of School of Environmental Engineering in University of Seoul.
Research Interests
- Understanding molecular mechanism of toxicity of environmental chemicals using multi-OMICS and systems toxicology approach
- Development of toxicity prediction model based on toxicity big data and machine learning approach
- Development of Adverse Outcome Pathway (AOP) for environmental chemicals toxicity screening
- Understanding epigenetic mechanism in environmental chemicals-induced toxicity and disease development using multi-models
- Understanding mechanism of environmental pollution-induced epigenetic and evolutionary changes in eco-toxicologically relevant species
Research Keywords
Systems Toxicology, Computational Toxicology, Nanotoxicology, Ecotoxicology, Environmental Epigenetics, Adverse Outcome Pathway, High Throughput Screening, Multi-OMICS
Educations
1998 | University of Paris-Sud (XI), France | PhD in Environmental Toxicology |
1993 | Seoul National University, Republic of Korea | MS in Environmental Planning |
1991 | Seoul National University, Republic of Korea | BS in Biology |
Ph.D Thesis : Étude des effets biochimiques et écophysiologiques du bichromate de potassium et du fénitrothion sue Chironomus riparius (Meigen) (Diptères, Chironomidae) en vue de l`identification expérimentale de biomarqueurs.
Ph.D Thesis supervisor : Prof. François Ramade, University of Paris-Sud (XI), France
Professional Experience
2002- | Assistant, Associate, Full Professor, School of Environmental Engineering, University of Seoul |
2010-2011 | Visiting Professor, Nicolas School of Environment, Duke University, USA |
1999-2002 | Post-doc Fellow, Seoul National University, Medical School |
Service in Academic Societies
2020 ~ 2021 | Korean Society of Environmental Toxicology and Health, Vice President |
2015 ~ | SETAC OMICS Global Adversary Group, Steering Committee |
2013 ~ | SETAC EVOGENERATE working group (in ERA Global AG), Member |
2014 ~ | Korean Society of Environmental Toxicology and Health, Research Committee Chair |
2014 ~ | Korean Society of Toxicology, Scientific Committee Member |
2016 ~ 2017 | The 12th International Conference and 5th Asian Congress on Environmental Mutagens (ICEM2017/ACEM 2017), Scientific Program Committee Member |
2012 ~ | Environmental Health and Toxicology, Associated Editor |
2014 ~ | Toxicological Research, Associated Editor |
2007 ~ 2016 | Environmental Engineering Research, Associated Editor |
2014 ~ 2015 | The 7th Asian Conference on Toxicology (ASIATOX) |
2012 ~ 2013 | The 13th International Conference on Toxicology (ICT), Steering Committee |
2012 ~ 2013 | The 2nd International Conference on Environmental OMICS (EOMICS), Program Co-Chair |
2012 ~ 2013 | Korean Society of Environmental Toxicology and Health, Secretary General |
2009 ~ 2011 | Korean Journal of Environmental Toxicology, Editor-in-Chief |
2017 | SETAC Europe 27th Annual Meeting (Brussels), 21st century Ecotoxicology and Human toxicology: Applications and perspectives for the use of OMICs data, Session co-chair |
2016 | The 10th SETAC Asia/Pacific Conference, Environmental OMICS, Session co-chair |
Service for Governmental Agencies
2019-2020 | Korean Presidential Adversary Council on Science and Technology, Member 대통령직속 국가과학기술 자문회의 자문위원 | |
2018-2020 | Korean National Research Foundation, ICT and Convergence Research, Review Board 한국연구재단 기초연구본부 ICT융합연구단 전문위원 | |
2019-2022 | Korean Ministry of Environment, Biocide Council Member 환경부 생활화학제품 및 살생물제 관리워원회 위원 | |
2018 | The Korean Federation of Science and Technology Societies, Member 과학기술총연합회 국민생활과학기술지원센터 운영위원 | |
2017 | Korean Ministry of Food and Drug Safety, Korea National Toxicology Program (KNTP), Member 독성시험평가 전문위원회 (KNTP) (식약처), 위원 | |
2016 | Korean Ministry of Environment, Committee for the Safety of household products, Member 생활화학제품 안전성 검증위원회 (환경부), 검증위원 | |
2015-2016 | Korean Ministry of Food and Drug Safety, Research Fellow board member 식품안전정책위원회, 화학물질분야 (식약처), 전문위원 | |
2015 | Committee for Off-site Risk Assessment and Risk Management Plan, Member 장외영향평가서 위해관리계획 위원회 (화학물질안전원), 검토위원 | |
2009-2010 | Korean Ministry of Trade, Industry and Energy, Mine Reclamation Corp. 한국광해관리공단 (산업통상자원부), 비상임이사 |